What are the recent trends in Structural Biology and Drug Discovery? - Insights from the PSDI conference
The rapid advancements in structural biology techniques are revolutionizing drug discovery. We had the opportunity of exploring these breakthroughs at the PSDI Conference in Paris, November 2024.
Curious about the highlights? Check out our latest blog post by Elisa Martino, where she shares key insights from the event »
Antibody developability: How to effectively navigate challenges and opportunities in predicting antibody properties?
Explore the insights from the expert panel about the current landscape, challenges, and transformative potential of AI/ML technologies in supporting antibody developability.
Evaluating protein-protein interactions in AF3 predicted complexes: a PD-1 case study
Can protein-protein complex models generated by AF3 effectively serve as starting points for predicting protein-protein interactions and identifying binding hotspots, thus facilitating drug design?
Using our software, 3decision®, we evaluated the accuracy of the AF3 models using Programmed cell death protein 1 (PD-1) complexes as a case study.
Leverage Experimental and in Silico 3D Protein Structures to Accelerate SBDD Projects
Gaining structural insights rapidly at the onset of a Structure-Based Drug Discovery project is key to driving the development of novel compounds. In this article, we illustrate the structure registration capabilities of 3decision® through a use case reproducing the identification of next-generation RXR targeting compounds.
How to best exploit 3D protein structures for ideation in SBDD
Explore the insights from industry experts on how to manage vast 3D protein structures to facilitate new design ideas in SBDD
Understanding selectivity of CLK kinase inhibitors: structural insights with 3decision®
Gain valuable insights into the selectivity of CLK kinase inhibitors with 3decision®. In this use case, we will show you the data sets preparation and binding mode analysis of the CLK kinase inhibitors’ using some of the 3decision’s cool features adapted to this specific scientific use case.
The impact of AlphaFold in drug discovery and emerging ML-methods
Following our Discngine Labs event and discussion with scientists in early drug discovery, we have summarized insights and experiences of the community on how they use AlphaFold technology to make it more suitable for drug discovery projects.